Metformin is an oral antidiabetic drug in the biguanide class. He is the first-line drug of choice for the treatment type 2 diabetes, particularly among the overweight and obese individuals and those with normal kidney function buy metformin . Evidence is also mounting for its efficiency in gestational diabetes, although security concerns still hinder widespread use in this context. It is also used in treating polycystic ovarian syndrome and has been investigated in other diseases where insulin resistance can be important.
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In a phase IIa study in patients with the second fasting glucose and impaired glucose tolerance, GFT505 treatment reduced fasting glucose and insulin concentrations and improved HOMA-IR, suggesting improved insulin sensitivity. This test also confirmed the beneficial effects of GFT505 on plasma lipids, apolipoproteins and markers of inflammation.
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GFT505 was well tolerated and no patient had to leave the study early because of side effects.
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Development of malaria was delayed in the other two vaccinated volunteers. Brian Greenwood and Dr Geoffrey Targett, London School of Hygiene and Tropical Medicine, UK, said: ?If the immunity induced by malaria parasites is all very specific to the strain, this could be more problems for those working on vaccines based on this model.
Source: http://www.exercise24.org/?p=474
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